Forests of the southeastern United States are subject to periodic disturbances through forest management practices, including timber harvest. Disturbances within these forests act to open forest canopies, which often releases shade intolerant, shrub species. Within this region, approximately 26 native species of the genus Rubus (e.g., blackberry and raspberry: hereinafter, Rubus) persist for long periods in the soil seedbanks of these forests and propagate quickly after release, often after a disturbance and opening of the forest canopy. Additionally, their short lifespan, rapid growth, shallow root depth, shade intolerance, and high levels of nutrient uptake enhance Rubus’s ability to quickly colonize sites and dominate the understory. Often maligned as a bane to human mobility, Rubus supports vertebrate and invertebrate communities, particularly during early successional periods, but often through the entire life of the forest. Through a series of evaluations from managed, working forests to high elevation balds, we showcase the function of Rubus as keystone species in ecosystems of the southeastern United States. We draw on research illustrating Rubus as a base of trophic relationships from invertebrate to vertebrate communities, as well as a structure that influences microclimate, reduces erosion, promotes nutrient retention, and provides pollination services, food, thermal cover, and refugia to numerous wildlife species. Many management actions undertaken in the southeastern United States seek to curtail the propagation and growth of Rubus. While some control of Rubus may be advocated to release herbaceous groundcover and enhance the growth and development of trees, in many cases, controlling Rubus through mechanical or chemical treatments reduces the aforementioned benefits Rubus provides these ecosystems. Supporting the generation of Rubus in disturbed sites, while also developing management strategies that capitalize on Rubus’ benefits, can enhance the numerous ecological services provided.